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通道
种类
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阳性对照
（参考）
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参考文献
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Cav1.2 (L-type)
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尼非地平(Nifedipine)
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Shen J et al Comparison of L-type calcium channel
blockade by nifedipine and/or cadmium in guinea pig ventricular myocytes JPET,
2000；294:562–70
Zahradnık I, Minarovic, I and Zahradnıkova A Inhibition of the cardiac
L-typec calcium channel currentby antidepressant drugs JPET,2008；324:977–84
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hERG
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西沙必利(Cisapride)
或特非那定(Terfenadine)
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Helliwell R, Recording hERG
potassium currents and assessing the effects of compounds using the
whole-cell patch-clamp technique Jonathan D Lippiat (ed ), Methods in Molecular Biology,
Potassium Channels, 2008；491: 279–95
Kamiya K et al Molecular determinants of hERG channel block
by terfenadine and cisapride J Pharmacol Sci,2008；108:301-7
Gintant GA et al Utility of hERG assays as surrogate markers
of delayed cardiac repolarization and QT safety ToxicolPathol,
2006；34:81-90
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Kv1.5
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4-氨基吡啶(4-Aminopyridine，4-AP)
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De
Biasi M et al Open channel block of
human heart hKv1 5 by the beta-subunit hKv beta 1 2 Am J
Physiol 1997 272: H2932-41 Lagrutta A et al Novel, potent
inhibitors of human Kv1 5 K+ channels and ultrarapidly activating
delayed rectifier potassium current JPET,2006;317:1054-63
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Kv4.3
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氟卡尼(又名哌氟酰胺，Fleca-
inide)或
4-AP
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Radicke S et al Effects of MiRP1 and DPP6 β-subunits on the
blockade induced by flecainide of KV4 3/KchIP2 channels Br J
Pharmacol 2008, 154: 774–86
Fischer
F et al Inhibition of cardiac Kv1 5
and Kv4 3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode
of action Naunyn Schmiedebergs Arch Pharmacol, 2013, online, Jul
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KvLQT1/minK
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二乙酰醇293B (Chromanol-293B)
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Yang WP et al KvLQT1, a voltage-gated potassium channel
responsible forhuman cardiac arrhythmias PNAS,
1997; 94:4017- 4021
Seebohm
G et al Molecular determinants of
KCNQ1 channel block by a benzodiazepine Mol
Pharmacol, 2003, 64:70-7
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Nav1.5
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利多卡因(Lidocaine)
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Wu L et al Role of late sodium current in modulating
the proarrhythmic and antiarrhythmic effects of quinidine Heart Rhythm, 2008；5: 1726-34
McNulty,
MM andHanck ,DA State-dependent mibefradil block of Na+
channels Mol Pharmacol, 2004； 66:1652-61
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Kir2.1
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钡(Barium)或氯喹(Chloroquine)
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Rodriguez-Menchaca AA et al ,
The molecular basis of chloroquine block of the inward rectifier Kir2 1
channel PNAS, 2008；105:1364-8
Schram G et al Barium block of Kir2 and human cardiac inward
rectifier currents:evidence for subunit-heteromeric contribution to native
currents Cardiovasc Res, 2003, 59: 328-38
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